WASHINGTON | Monday, December 13, 2010 12: 17 pm EST
WASHINGTON (Reuters) - stem cells can be transformed into cell pancreatic needs to treat diabetes and complex layers of intestinal tissue, scientists have demonstrated in two experiments reported Sunday.
In one, a team has transformed immature sperm in pancreatic tissue, so that another team transformed into complex layers of intestinal tissue embryonic stem cells.
Two studies show new ways of using stem cells that are master cells of the body and can come from various sources.
A team at Georgetown University in Washington, D.c. has worked with masters of the cells that give rise to sperm in males spermatogonial stem cells.
Ian Gallicano and his colleagues used manufactured from spermatogonial stem cells derived from germ, pluripotent stem cells. They fed these cells in the laboratory with compounds designed to make these cells to begin producing insulin to act as the pancreatic beta cells.
When transplanted into diabetic mice, these cells produce insulin, acting as the pancreatic beta cells that body destroyed by error in type 1 diabetes, the Gallicano team told a meeting of the American Society of cell biology in Philadelphia.
Currently, children and young adults with diabetes type 1 must take insulin for life.
Some may be treated with the so-called Edmonton Protocol in which missing pancreatic cells are transplanted from corpses. But there is a shortage of these cells and patients may suffer from graft - cross - host disease if the cells are not a good match.
Said Gallicano cells own men could be used as a source of their transplant, and he said that perhaps approach may work for women too. "These cells come from human testis, here, the work is not necessarily male-centric," they wrote. "These fundamental aspects could easily be applied to the female equivalent, oocytes.".
Separately, James Wells and colleagues at Hospital Medical Center of Cincinnati, Ohio children turned two types of stem cells into complex layers of intestinal tissue.
They used two human embryonic stem - embryos day - and - induced pluripotent stem cells produced from ordinary cells transformed with the introduction of certain genes cells.
The two types have the power to give birth to all types of cells and tissues in the body when it is grown in the laboratory as Georgetown team.
Writing in the journal nature, Wells team showed that they could transform these cells in what they called organoids - lots of intestinal tissue layers of cells that make up the intestine, including muscle cells and cell line inside the digestive tract and produce several vital compounds.
These organoids can be used for the study of intestinal diseases such as Fasciitis enterocolitis, inflammatory bowel diseases and syndromes in short bowel and perhaps could be used to treat a day, said Wells team.
(Editing by Eric Walsh)
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